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Memory B cell subsets and plasmablasts are lower in early than in long-standing Rheumatoid Arthritis
Scritto da BMC Immunology   
AllergologiaBackground:Alterations of B cell subset distribution have been described in the peripheral blood (PB) of rheumatoid arthritis (RA) patients, but no data are available on differences between the onset and the established phases of the disease. The pu ... ...
An increase of CD83 + dendritic cells ex vivo correlates with increased regulatory T cells in patients with active eosinophilic granulomatosis and polyangiitis
Scritto da BMC Immunology   
AllergologiaBackground:Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease characterized by the presence of allergic granulomatosis and necrotizing vasculitis with eosinophilic infiltration. The etiology of EGPA is unknown. Dendritic cells (D ... ...
Anti-cancer properties of gastropodan hemocyanins in murine model of colon carcinoma
Scritto da BMC Immunology   
AllergologiaBackground:Various immunotherapeutic approaches have been used for the treatment of cancer. A number of natural compounds are designed to repair, stimulate, or enhance the immune system response. Among them are the hemocyanins (Hcs) - extracellular ... ...
Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings
Scritto da BMC Immunology   
AllergologiaBackground:Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ... ...
Limited role for ASC and NLRP3 during in vivo
Scritto da BMC Immunology   
AllergologiaBackground:The inflammasome is an intracellular protein complex triggered by exposure to intracellular pathogens, its components or other endogenous proteins. It leads to the activation of and subsequent release of proinflammatory cytokines such as ... ...
Capturing needles in haystacks: a comparison of B-cell receptor sequencing methods
Scritto da BMC Immunology   
AllergologiaBackground:Deep-sequencing methods are rapidly developing in the field of B-cell receptor (BCR) and T-cell receptor (TCR) diversity. These promise to revolutionise our understanding of adaptive immune dynamics, identify novel antibodies, and allow m ... ...
Interferon-¿ regulates growth and controls Fc¿ receptor expression and activation in human intestinal mast cells
Scritto da BMC Immunology   
AllergologiaBackground:Development and function of tissue resident mast cells (MCs) is tightly controlled by various cytokines, most of which belong to the typical T helper (Th) 2-type cytokines such as IL-3 and IL-4. The effects of the Th1-type cytokine IFN-? ... ...
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