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In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases
Scritto da BMC Immunology   
AllergologiaBackground:Near universal administration of vaccines mandates intense pharmacovigilance for vaccine safety and a stringently low tolerance for adverse events. Reports of autoimmune diseases (AID) following vaccination have been challenging to evalua ... ...
Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae
Scritto da BMC Immunology   
AllergologiaBackground:Intracellular pathogens have devised various mechanisms to subvert the host immune response in order to survive and replicate in host cells. Here, we studied the infection of human blood monocytes with the intracellular pathogen C. pneumo ... ...
Genomic locus on chromosome 1 regulates susceptibility to spontaneous arthritis in mice deficiency of IL-1RA
Scritto da BMC Immunology   
AllergologiaBackground:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region fro ... ...
Orphan nuclear receptor Nur77 Inhibits Oxidized LDL-induced differentiation of RAW264.7 murine macrophage cell line into dendritic like cells
Scritto da BMC Immunology   
AllergologiaBackground:Nur77 is an orphan nuclear receptor expressed in human atheroma. In vascular cells in vitro, Nur77 expression is induced by pro-inflammatory factors, such as oxidized LDL (oxLDL).Methods:We analyze the role of Nur77 in the oxLDL-induced ... ...
RAGE controls leukocyte adhesion in preterm and term infants
Scritto da BMC Immunology   
AllergologiaBackground:Insufficient leukocyte recruitment may be one reason for the high incidence of life-threatening infections in preterm infants. Since the receptor of advanced glycation end products (RAGE) is a known leukocyte adhesion molecule and highly ... ...
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
Scritto da BMC Immunology   
AllergologiaBackground:The Syrian golden hamster (Mesocricetus aureus) has been used as a model to study infections caused by a number of human pathogens. Studies of immunopathogenesis in hamster infection models are challenging because of the limited availabil ... ...
The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases
Scritto da BMC Immunology   
AllergologiaBackground:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers.Methods:The release of sTLR2 and ... ...
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