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Medicina
Altered pathways and colorectal cancer prognosis
InternaThe identification of molecular markers with prognostic value in colorectal cancer is a challenging task that is needed to define therapeutic guidelines. Clinical factors are insufficient to identify those patients with stage II at risk of relapse or ... ...
 
Improved survival among colon cancer patients with increased differentially expressed pathways
InternaBackground:Studies of colorectal cancer (CRC) have shown that hundreds to thousands of genes are differentially expressed in tumors when compared to normal tissue samples. In this study, we evaluate how genes that are differentially expressed in col ... ...
 
The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
InternaBackground:The escalating use of prescribed drugs has increasingly raised concerns about polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially serious drug-drug interactions in a stable geographical population bet ... ...
 
Better health intelligence: a new era for civil registration and vital statistics
InternaThe impetus and opportunities for improving birth, death, and cause of death data have never been more propitious. Renewed country commitment to strengthen vital registration systems is clearly evident, supported by nascent regional coalitions of tec ... ...
 
Depression sum-scores don't add up: why analyzing specific depression symptoms is essential
InternaMost measures of depression severity are based on the number of reported symptoms, and threshold scores are often used to classify individuals as healthy or depressed. This method ? and research results based on it ? are valid if depression is a sing ... ...
 
Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials
InternaBackground:The Surviving Sepsis Campaign guidelines have proposed early goal-directed therapy (EGDT) as a key strategy to decrease mortality among patients with severe sepsis or septic shock. However, its effectiveness is uncertain.Methods:We sear ... ...
 
The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study
InternaBackground:Low haemoglobin concentrations may be predictive of incident tuberculosis (TB) and death in HIV-infected patients receiving antiretroviral therapy (ART), but data are limited and inconsistent. We examined these relationships retrospective ... ...
 
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