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Medicina
Towards identification of true cancer biomarkers
InternaBackground:Most of newly discovered cancer biomarkers fail in the clinic because they lack sensitivity and/or specificity. The current explosion in knowledge of the mutational spectrum of many cancer types, as a result of whole exome and whole genom ... ...
 
Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA
InternaBackground:Several non-invasive prediction scores for non-alcoholic fatty liver disease (NAFLD) have been developed, but their performance has not been compared and validated in the same population, and whether these prediction scores can predict cl ... ...
 
Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysis
InternaBackground:Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identifi ... ...
 
Feasibility of HIV point-of-care tests for resource-limited settings: challenges and solutions
InternaImproved access to anti-retroviral therapy increases the need for affordable monitoring using assays such as CD4 and/or viral load in resource-limited settings. Barriers to accessing treatment, high rates of loss to initiation and poor retention in c ... ...
 
Environmental stress and epigenetic transgenerational inheritance
InternaPrevious studies have shown a wide variety of environmental toxicants and abnormal nutrition can promote the epigenetic transgenerational inheritance of disease. More recently a number of studies have indicated environmental stress can also promote e ... ...
 
Predicting outcome from dengue
InternaDengue is emerging as one of the most abundant vector-borne disease globally. Although the majority of infections are asymptomatic or result in only a brief systemic viral illness, a small proportion of patients develop potentially fatal complication ... ...
 
STORIES statement: Publication standards for healthcare education evidence synthesis
InternaBackground:Evidence synthesis techniques in healthcare education have been enhanced through the activities of experts in the field and the Best Evidence Medical Education (BEME) collaborative. Despite this, significant heterogeneity in techniques an ... ...
 
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