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Clinical development of cancer therapeutics that target metabolism

Glucose and glutamine metabolism in cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the production of adenosine triphosphate and the anabolic precursors needed for survival, growth ... ...

Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: results from the MAGGIC individual patient data meta-analysis

Background: Anaemia is common among patients with heart failure (HF) and is an important prognostic marker.

Aim: We sought to determine the prognostic importance of anaemia in a large multinational pooled dataset of prospecti ... ...

Do traditional risk stratification models for cerebrovascular events apply in irradiated head and neck cancer patients

Background: Primary radical radiotherapy (RT) for head and neck cancer (HNC) often results in significant radiation dose to the carotid arteries.

Aim: We assessed whether HNC patients are at increased risk of a cerebrovascula ... ...

Attitudes to outcomes measured in clinical trials of cardiovascular prevention

Background: Selecting outcome measures in cardiovascular prevention trials should be informed by their importance to selected populations. Major vascular event outcomes are usually prioritized in these trials with considerably less attenti ... ...

Association of HaeIII single nucleotide polymorphisms in the SLC2A1 gene with risk of diabetic nephropathy; evidence from Kurdish patients with type 2 diabetes mellitus

Aims: Given the growing rate of patients with type 2 diabetes mellitus, uncovering the effects of gene polymorphism on diabetes pathogenesis has attracted a lot of attention. Because glucose transporter 1 is involved in glucose uptake, the ... ...

Epidemiology of adolescent substance use in London schools

Background: Alcohol and substance use in adolescence can be associated with a range of health, emotional, social, behavioural and legal problems. There has been a change in the recreational drugs available to users in recent years; however ... ...

Emerging therapies for mitochondrial disorders

Mitochondrial disorders are a diverse group of debilitating conditions resulting from nuclear and mitochondrial DNA mutations that affect multiple organs, often including the central and peripheral nervous system. Despite major advances in our un ... ...

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