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Patologia clinica
Clinicopathological correlates of adrenal Cushing's syndrome
Scritto da Journal of Clinical Pathology   
Patologia-clinica

Endogenous Cushing's syndrome is a rare endocrine disorder that incurs significant cardiovascular morbidity and mortality, due to glucocorticoid excess. It comprises adrenal (20%) and non-adrenal (80%) aetiologies. While the majority of cases ar ... ...

 
Cell cycle marker expression in benign and malignant intraductal papillary lesions of the breast
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

The diagnosis of intraductal papillary lesions of the breast on core biopsy remains challenging in pathology, with most patients requiring formal surgical excision for a definitive diagnosis. The aim of this study was to determ ... ...

 
Quantification of histochemical stains using whole slide imaging: development of a method and demonstration of its usefulness in laboratory quality control
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

Histochemical staining of tissue is a fundamental technique in tissue diagnosis and research, but it suffers from significant variability. Efforts to address this include laboratory quality controls and quality assurance scheme ... ...

 
CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinica ... ...

 
Physical and methylation status of human papillomavirus 16 in asymptomatic cervical infections changes with malignant transformation
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

To evaluate how the genetic and epigenetic profile of human papillomavirus 16 (HPV16) changes from asymptomatic cervical infections to cervical cancer (CaCx) development.

Methods

HPV16 physical statu ... ...

 
Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

Assessing whether next-generation DNA sequencing (NGS) can be used to screen prostate cancer for multiple gene alterations in men routinely diagnosed with this disease and/or who are entered into clinical trials. Previous studi ... ...

 
Improved detection of hereditary haemochromatosis
Scritto da Journal of Clinical Pathology   
Patologia-clinicaAims

There is high prevalence of hereditary haemochromatosis (HH) in North European populations, yet the diagnosis is often delayed or missed in primary care. Primary care physicians frequently request serum ferritin (SF) estimation ... ...

 
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