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Istopatologia del cuore: febbre reumatica

Reumatologia
Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: results from the Danish nationwide DANBIO registry
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaBackground/purpose

Early diagnosis of inflammatory rheumatic diseases is important in order to improve long-term outcome. We studied whether delay in diagnosis (time between onset of symptoms and establishment of diagnosis) in patie ... ...

 
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaObjective

A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune dise ... ...

 
PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaObjectives

To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease.

Methods

Linkage diseq ... ...

 
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaIntroduction

Rheumatoid arthritis (RA) patients can be classified based on presence or absence of anticitrullinated peptide antibodies (ACPA) in their serum. This heterogeneity among patients may reflect important biological differe ... ...

 
Significant associations of antidrug antibody levels with serum drug trough levels and therapeutic response of adalimumab and etanercept treatment in rheumatoid arthritis
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaObjective

To evaluate the associations between (1) antidrug antibody (ADAb) and therapeutic response, (2) ADAb and serum drug trough levels and (3) serum drug levels and therapeutic responses in rheumatoid arthritis (RA) patients re ... ...

 
SAMHD1 prevents autoimmunity by maintaining genome stability
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaObjectives

The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi–Goutière ... ...

 
Signature of circulating microRNAs in osteoarthritis
Scritto da Annals of the Rheumatic Diseases current issue   
ReumatologiaBackground

Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the kne ... ...

 
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