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Nefrologia
Beat it early: putative renoprotective haemodynamic effects of oral hypoglycaemic agents
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Diabetic kidney disease represents a considerable burden; around one-third of patients with type 2 diabetes develop chronic kidney disease. In health, the kidneys play an important role in the regulation of glucose homeostasis via glucose utiliza ... ...

 
Highlights of the 2015 ERA-EDTA congress: chronic kidney disease, hypertension
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

This paper reports the highlights in the field of chronic kidney disease (CKD) and hypertension of the last European Renal Association (ERA-EDTA) Congress (London, May 21–24, 2016). The items include an European survey on CKD epidemiology a ... ...

 
Pro: Cyclophosphamide in lupus nephritis
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Based on efficacy and toxicity considerations, both low-dose pulse cyclophosphamide as part of the Euro-Lupus Nephritis protocol and mycophenolate mofetil (MMF) with corticosteroids may be considered for induction of remission in patients with pr ... ...

 
Con: Cyclophosphamide for the treatment of lupus nephritis
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Kidney involvement is a major determinant for morbidity and mortality in patients with systemic lupus erythematosus. The treatment target of lupus renal disease is to induce and maintain remission and to minimize disease or treatment-related como ... ...

 
Moderator's view: Cyclophosphamide in lupus nephritis
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Mycophenolate mofetil was recently accepted as the effective induction treatment of lupus nephritis, with the potential to replace cyclophosphamide or at least expand our therapeutic armamentarium in patients with this lifelong disease often requ ... ...

 
Mitochondria: a therapeutic target in acute kidney injury
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and morbidity. It is a risk factor for the development and progression of chronic kidney disease. Presently, no effective treatment for AKI is available, ... ...

 
Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies
Scritto da Nephrology Dialysis Transplantation - current issue   
Nefrologia

Muscle wasting (or sarcopenia) is a common feature of the uremic phenotype and predisposes this vulnerable patient population to increased risk of comorbid complications, poor quality of life, frailty and premature death. The old age of dialysis ... ...

 
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