APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study
Scritto da BMC Neurology   
NeurologiaBackground:Cerebrospinal fluid (CSF) biomarkers A?1-42, t-tau and p-tau have a characteristic pattern in Alzheimer?s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.Methods:Adults with chronic treated HIV ... ...
A patient develops transient unique cerebral and cerebellar lesions after unruptured aneurysm coiling
Scritto da BMC Neurology   
NeurologiaBackground:We describe a case of a very unusual complication following a coiling procedure in which the patient developed transient unique cerebral and cerebellar lesions. Lesions were examined not only by magnetic resonance imaging (MRI) but also b ... ...
Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases
Scritto da BMC Neurology   
NeurologiaBackground:Proteinase-activated receptor 2 (PAR-2) has been shown to promote both neurotoxic and neuroprotective effects. Similarly, other routinely used nonspecific markers of neuronal damage can be found in cerebrospinal fluid (CSF) and can be use ... ...
Decision Tree Analysis of Genetic Risk for Clinically Heterogeneous Alzheimer's Disease
Scritto da BMC Neurology   
NeurologiaBackground:Heritability of Alzheimer?s disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ?4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numerous other common variants c ... ...
Chronic inflammatory demyelinating polyneuropathy-like neuropathy as an initial presentation of Crohn's disease
Scritto da BMC Neurology   
NeurologiaBackground:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare complication of Crohn's disease (CD), and it is uncertain whether it is associated with CD itself or with its treatment. We describe a case of CIDP-like neuropathy as an ... ...
Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a historical-control phase III study
Scritto da BMC Neurology   
NeurologiaBackground:Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD) anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It is extensively converted after oral administration to eslicarbazepine, and is believed to exe ... ...
Retraction Note: Gene expression profiling analysis of the putamen for the investigation of compensatory mechanisms in Parkinson's disease
Scritto da BMC Neurology   
NeurologiaNo description available ... ...
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