Neurologia
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Scritto da Brain - current issue   
Neurologia

Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex process that is critical fo ... ...

 
Association of inclusion body myositis with T cell large granular lymphocytic leukaemia
Scritto da Brain - current issue   
Neurologia

See Hohlfeld and Schulze-Koops (doi:10.1093/brain/aww053) for a scientific commentary on this article.

Inclusion body myositis and T cell large granular lymphocytic leukaemi ... ...

 
TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress
Scritto da Brain - current issue   
Neurologia

Despite intense investigation, the mechanisms of the different forms of trigeminal neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 channel (encoded by TRPA1) has been reported to contribute to ... ...

 
SYNE1 ataxia is a common recessive ataxia with major non-cerebellar features: a large multi-centre study
Scritto da Brain - current issue   
Neurologia

Mutations in the synaptic nuclear envelope protein 1 (SYNE1) gene have been reported to cause a relatively pure, slowly progressive cerebellar recessive ataxia mostly identified in Quebec, Canada. Combining next-generation sequencing techn ... ...

 
Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury
Scritto da Brain - current issue   
Neurologia

Following traumatic spinal cord injury, acute demyelination of spinal axons is followed by a period of spontaneous remyelination. However, this endogenous repair response is suboptimal and may account for the persistently compromised function of ... ...

 
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
Scritto da Brain - current issue   
Neurologia

Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43, encoded by TARDBP) neuronal cytoplasmic inclusions are the pathological hallmark in ~95% of amyotrophic lateral sclerosis and ~60% of frontotemp ... ...

 
In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS
Scritto da Brain - current issue   
Neurologia

Polyspecific T cells recognizing multiple distinct self-antigens have been identified in multiple sclerosis and other organ-specific autoimmune diseases, but their pathophysiological relevance remains undetermined. Using a mouse model of multiple ... ...

 
<< Inizio < Prec. 1 2 3 4 5 6 7 8 9 10 Succ. > Fine >>

Pag 1 di 3274