Neurologia
Differential diagnosis of Mendelian and mitochondrial disorders in patients with suspected multiple sclerosis
Scritto da Brain - current issue   
Neurologia

Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. T ... ...

 
The perception of touch and the ventral somatosensory pathway
Scritto da Brain - current issue   
Neurologia

In humans, touching the skin is known to activate, among others, the contralateral primary somatosensory cortex on the postcentral gyrus together with the bilateral parietal operculum (i.e. the anatomical site of the secondary somatosensory corte ... ...

 
In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography
Scritto da Brain - current issue   
Neurologia

Transthyretin familial amyloid polyneuropathy is a rare, autosomal-dominant inherited multisystem disorder usually manifesting with a rapidly progressive, axonal, distally-symmetric polyneuropathy. The detection of nerve injury by nerve conductio ... ...

 
OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation
Scritto da Brain - current issue   
Neurologia

Hearing impairment is the second most prevalent clinical feature after optic atrophy in dominant optic atrophy associated with mutations in the OPA1 gene. In this study we characterized the hearing dysfunction in OPA1-linked disorde ... ...

 
Human spinal locomotor control is based on flexibly organized burst generators
Scritto da Brain - current issue   
Neurologia

Constant drive provided to the human lumbar spinal cord by epidural electrical stimulation can cause local neural circuits to generate rhythmic motor outputs to lower limb muscles in people paralysed by spinal cord injury. Epidural spinal cord st ... ...

 
Gait training facilitates central drive to ankle dorsiflexors in children with cerebral palsy
Scritto da Brain - current issue   
Neurologia

Foot drop and toe walking are frequent concerns in children with cerebral palsy. The main underlying cause of these problems is early damage and lack of maturation of the corticospinal tract. In the present study we investigated whether 4 weeks o ... ...

 
Evidence for brain glial activation in chronic pain patients
Scritto da Brain - current issue   
Neurologia

Although substantial evidence has established that microglia and astrocytes play a key role in the establishment and maintenance of persistent pain in animal models, the role of glial cells in human pain disorders remains unknown. Here, using the ... ...

 
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