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Obtaining an upper estimate of the survival benefit associated with surgery for mesothelioma [Original articles]
Toracica

Objective: This study aimed to obtain an upper estimate of any survival benefit conferred by resection in patients with a diagnosis of malignant pleural mesothelioma. Methods: We analysed published data concerning survival fr ... ...

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May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma [Original articles]
Toracica

Objectives: The expression of cyclooxygenase-2 (COX-2) and cell-cycle proteins (p21 and p27) proves useful in predicting prognosis and orientating therapy in many malignant tumours. Malignant pleural mesothelioma is an uncommon and ... ...

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Immunoreactivity of integrin-linked kinase in primary non-small-cell lung cancer and survival after curative resection [Original articles]
Toracica

Objective: Increased immunoreactivity of integrin-linked kinase (ILK) in the primary tumour is an adverse prognostic factor in a variety of preclinical and clinical models of human cancer. Here, we investigate the relationship betwe ... ...

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Serum vascular endothelial growth factors C and D in patients with oesophageal cancer [Original articles]
Toracica

Objective: Lymph node metastasis is a characteristic of malignant cancers and is observed more frequently in oesophageal cancer than in other digestive tract cancers, making it one of the most important prognostic factors. Vascular ... ...

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Preoperative introduction and maintenance immunosuppression therapy of oral-only tacrolimus, mycophenolate mofetil and steroids reduce acute rejection episodes after lung transplantation [Original art
Toracica

Objective: Immunosuppression therapy in lung transplantation (LTX) remains unsatisfactory due to a high incidence of infection and frequent acute rejection (AR), leading to early onset of the bronchiolitis obliterans syndrome (BOS). ... ...

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Long-term outcome of double-lung and heart-lung transplantation for pulmonary hypertension: a comparative retrospective study of 219 patients [Original articles]
Toracica

Objective: Whether double-lung transplantation (DLT) or heart–lung transplantation (HLT) is the best option in patients with pulmonary hypertension (PH) remains unclear. At our institution, patients with severe right ventricul ... ...

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Outcome of patients suffering from acute type B aortic dissection: a retrospective single-centre analysis of 135 consecutive patients [Original articles]
Toracica

Objectives: Acute uncomplicated Stanford type B aortic dissection (TBAD) is optimally managed with medical treatment. However, surgery and thoracic endovascular aortic repair (TEVAR) are occasionally indicated, particularly when end ... ...

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